Murray is scheduled to undergo further testing on Tuesday, including an MRI, but a source told ESPN there is "little doubt that it's torn," referring to an ACL.
In his postgame news conference, Arizona coach Kliff Kingsbury said Murray's injury "doesn't look good, but we'll know more in the morning."
"Obviously, it didn't look good," Kingsbury said. "I've never seen him in that type of shape, so I assumed it wasn't good."
An MRI and additional tests will confirm the severity of Murray's injury. A torn ACL would sideline the QB for the remainder of 2022 and potentially part of the 2023 campaign considering such damage typically requires nine to 12 months of rehabilitation. Murray has battled injuries in each of his four NFL seasons since entering in 2019, sitting out three games in 2021 due to ankle issues. An ACL tear, however, would represent the most significant medical blow of his career, and potentially prompt Arizona to rely on McCoy, or another veteran replacement, into next season.