During the 2006 Chicago Bears season, Grossman became the first Bears quarterback to start all sixteen games since Erik Kramer in 1995.[30] In a season dubbed as a "roller coaster ride" by Grossman himself, the fourth-year quarterback had several productive performances, which were seemingly diluted by a handful of turnover-ridden games, especially in Week 6 against the Arizona Cardinals, where Grossman fumbled twice and threw four interceptions.
During that game, Grossman had the lowest passer rating in a win since 2000 (20+ attempts) with a 10.2. It was a 24-23 win, where he went 14/37, with 144 yards and 4 INTs.